Please
join us - NevBio evening event:
Dr.
Craig Dees, CEO of Provectus Pharmaceuticals, Inc.
"Promising
Results with Melanoma Lesions in Phase II Trial of 80 subjects"
Wednesday,
June 5th, 5:30 pm
Panevino
Restaurant (New location)
RSVP
here. $10 (Students, researchers & anyone involved in cancer - no charge)
Provectus
Pharmaceuticals, Inc.is an oncology and dermatology biopharmaceutical company
which is conducting Phase 2 trials of its drug, PV-10 as a treatment for
metastic melanoma.
PV-10
selectively destroys cancer cells without harming surrounding healthy tissue.
As reported in Practical Dermatology, the phase II open label, single-arm
trial, 80 subjects with AJCC Stage III/ IV melanoma received treatment for one
to 10 target lesions and up to 10 non-target lesions; at least one target
lesion had to have biopsy confirmation of the diagnosis. Target lesions were
>0.2cm diameter. Intralesional dosing was provided at 50 percent of the
calculated lesion volume. Retreatment was allowed at weeks 8, 12, or 16, and
all subjects were followed for 52 weeks.
According
to final outcome data provided by Provectus, a Complete Response (CR: complete
disappearance of the tumor) of PV-10 injected lesions was achieved in 26
percent of subjects, Partial Response (PR: at least a 30 percent reduction in
tumor volume) was seen in 25 percent of subjects, and Stable Disease (SD: less
than 20 percent increase in tumor volume) was seen in 18 percent of subjects.
Less than one-third (31 percent) of subjects experienced Disease Progression
(DP: 20 percent or greater increase in tumor volume).
Dr.
Craig Dees & Provectus have had impressive results from their Phase 2 study
and are preparing for Phase 3.
We
want to thank Dominic Rodrigues for generously supporting the effort to have
Dr. Dees speak in Las Vegas.
There's
a lot more to the story of Dr. Dees & Provectus. I hope you can join us on
Wednesday, June 5th.