Dr.
Bryan Spangelo's New Treatment for Cancer
Novel
Formulations of Cisplatin - Thurs, May 24th
I
am interested in helping to solve two fundamental problems within the area of
cancer chemotherapeutics. We know that
cancer drugs can be toxic resulting in side effects. We also know that once a cancer returns from
a previous remission that a cancer drug which was effective before will no
longer prevent the cancer from spreading (i.e., the tumor is resistant).
Dr.
Bryan Spangelo's talk:
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Overview of chemotherapy
*
Cisplatin and other chemotherapeutic options
*
How his formulations may improve the use of platinum-based chemotherapeutics.
*
Thursday, May 24th 11:30 & 12 noon program & Lunch.
*
McCormick & Schmicks 335 Hughes Center Dr. $30. (UNLV Students Free)
Dr.
Spangelo's lab and Dr. Pradip Bhowmik's lab in the UNLV Department of
Chemistry, are attempting to isolate novel chemotherapeutics with enhanced
potencies and efficacies.
We
(Dr. Spangelo & Dr. Bhowmik) have synthesized novel analogues of the platinum-containing
drug cisplatin. This drug is effective
for many solid tumors (colon, lung) but has severe side effects for the
patient. As for all chemotherapeutic drugs, cisplatin is less effective in
treating a cancer that has returned from remission. Our new drugs which also contain platinum are
much more effective in killing cancer cells in the test tube compared to
cisplatin, opening the possibility that these new drugs might be more effective
than cisplatin in lower doses.
Hopefully
our new cancer drugs may someday be useful in clinical settings for providing a
less-toxic alternative to cisplatin and to replace cisplatin for tumors that
come out of remission and are resistant to cisplatin. Dr. Bryan Spangelo
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